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Blood & Hemoglobin

What is the Mentzer Index and how does it differentiate Thalassemia from Iron Deficiency?

Direct Answer:

Mentzer Index is calculated as MCV divided by total RBC count. A ratio below 13 indicates high probability of Thalassemia Trait, whereas a ratio above 13 indicates Iron Deficiency Anemia.

In microcytic anemias (MCV < 80 fL), differentiating Thalassemia trait from nutritional iron deficiency is crucial to avoid inappropriate iron therapy.

Mentzer Index = MCV (fL) / RBC Count (million/µL)

Thalassemia trait features high RBC count relative to MCV, yielding a low ratio (<13). Confirmation requires Hemoglobin Electrophoresis / HPLC.

When to Seek Medical Care:

Consult a hematologist or physician for HPLC testing if your Mentzer Index is under 13.

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Clinical Disclaimer: This health information is provided for general educational purposes only and does not constitute medical diagnosis, advice, or treatment. Always consult a qualified physician regarding any medical condition.
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